PR Newswire
LAS VEGAS, March 5, 2026
The chronic rhinosinusitis with nasal polyps market growth is being driven by rising disease prevalence, greater awareness, and improved diagnostic rates. Advancements in biologic therapies are expanding treatment options and significantly boosting market demand. Additionally, the launch of emerging therapies such as Depemokimab (GlaxoSmithKline), Verekitug (UPB-101) (Upstream Bio), Lunsekimig (Sanofi), LY3650150 (Eli Lilly), and others will further propel the market growth.
LAS VEGAS, March 5, 2026 /PRNewswire/ — Recently published Chronic Rhinosinusitis with Nasal Polyps Market Insights report includes a comprehensive understanding of current treatment practices, chronic rhinosinusitis with nasal polyps emerging drugs, market share of individual therapies, and current and forecasted market size from 2022 to 2036, segmented into leading markets [the United States, the EU4 (Germany, France, Italy, and Spain), the United Kingdom, and Japan].
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Chronic Rhinosinusitis with Nasal Polyps Market Summary
- The total chronic rhinosinusitis with nasal polyps treatment market size is expected to grow positively by 2036 in the leading markets.
- The United States accounted for the largest CRSwNP treatment market size in 2025, compared to other major markets, including the EU4 countries (Germany, France, Italy, and Spain), the United Kingdom, and Japan.
- The 7MM accounted for 4.5 million diagnosed prevalent cases of CRSwNP in 2025, which are expected to increase during the study period.
- Leading CRSwNP companies, such as Upstream Bio, GlaxoSmithKline, Sanofi, Eli Lilly, and others, are developing new CRSwNP treatment drugs that can be available in the CRSwNP market in the coming years.
- The promising CRSwNP therapies in clinical trials include Verekitug (UPB-101), Depemokimab (GSK3511294), Lunsekimig, LY3650150, and others.
Discover what is the forecast for the global CRSwNP market @ https://www.delveinsight.com/sample-request/chronic-rhinosinusitis-with-nasal-polyps-market?utm_source=cision&utm_medium=pressrelease&utm_campaign=spr
Key Factors Driving the Growth of the Chronic Rhinosinusitis with Nasal Polyps Market
- Rising CRSwNP Disease Burden: CRSwNP is expected to see a rising disease burden over the forecast period (2026-2036), driven primarily by increasing prevalence, improved diagnosis, and evolving treatment approaches.
- Impact of Nucala and Xolair Approvals on CRSwNP Treatment: The coveted approvals of NUCALA and XOLAIR in the overall existing treatment have added effectiveness in treating CRSwNP.
- Launch of Emerging CRSwNP Therapies: The dynamics of the CRSwNP market are expected to change in the coming years due to the launch of emerging therapies such as Depemokimab (GlaxoSmithKline), Verekitug (UPB-101) (Upstream Bio), Lunsekimig (Sanofi), LY3650150 (Eli Lilly), and others.
Ramandeep Singh, Senior Consultant, Forecasting and Analytics at DelveInsight, said that the treatment strategies are shifting beyond conventional intranasal corticosteroids, systemic steroids, and surgery toward targeted biologic therapies, enabling more personalized and sustained disease control for patients.
Chronic Rhinosinusitis with Nasal Polyps Market Analysis
- The current treatment of CRSwNP includes corticosteroids (intranasal and systemic) in addition to anti-histamines, antibiotics, and NSAIDs, which are given depending on the patient’s need.
- When drug treatment doesn’t shrink or eliminate nasal polyps, endoscopic surgery is recommended to remove polyps and correct sinus problems that lead to inflammation and polyp development.
- After surgery, a corticosteroid nasal spray is recommended to prevent recurrence of nasal polyps along with biologics.
- Over the years, the US FDA has approved multiple corticosteroids and biologics for CRSwNP, including XHANCE (fluticasone propionate), SINUVA (mometasone furoate) sinus implant, PROPEL (mometasone furoate), DUPIXENT (dupilumab), XOLAIR (omalizumab), and NUCALA (mepolizumab).
- In February 2026, GSK reported that the European Commission approved EXDENSUR (depemokimab) as an add-on therapy with intranasal corticosteroids for adults with severe CRSwNP not adequately controlled with systemic corticosteroids and/or surgery.
- The approval of EXDENSUR was supported by Phase III SWIFT and ANCHOR trial data showing statistically significant and clinically meaningful improvements compared with standard of care alone.
- With this decision, EXDENSUR became the first and only ultra-long-acting biologic approved in the European Union for respiratory diseases, including severe CRSwNP.
- Several companies are actively working in the CRSwNP market. The launch of emerging drugs such as Depemokimab (GlaxoSmithKline), Verekitug (UPB-101) (Upstream Bio), Lunsekimig (Sanofi), LY3650150 (Eli Lilly), and others will change the market dynamics.
Chronic Rhinosinusitis with Nasal Polyps Competitive Landscape
CRSwNP pipeline possesses some drugs in late stage developments to be approved in the near future. Expected launch of emerging therapies, such as Depemokimab (GlaxoSmithKline), Verekitug (UPB-101) (Upstream Bio), Lunsekimig (Sanofi), LY3650150 (Eli Lilly), and others, are expected to further create a positive impact on the market.
Upstream Bio’s Verekitug is an engineered, fully human IgG1 monoclonal antibody that targets the TSLP receptor, blocking TSLP-driven pro-inflammatory signaling. In preclinical testing, it showed strong receptor occupancy and robust inhibition of TSLP pathways. Verekitug also reduced cytokine release from CD4+ T cells and ILC2s and completely prevented allergic skin responses in a non-human primate model, indicating potential effectiveness across multiple inflammatory conditions.
GSK is developing depemokimab as a treatment for CRSwNP. This humanized monoclonal antibody against interleukin-5 (IL-5) is designed to bind IL-5 with high affinity and provide long-lasting suppression of IL-5-dependent activity, supporting extended control of eosinophil-driven inflammation.
The anticipated launch of these emerging therapies are poised to transform the CRSwNP market landscape in the coming years. As these cutting-edge therapies continue to mature and gain regulatory approval, they are expected to reshape the CRSwNP market landscape, offering new standards of care and unlocking opportunities for medical innovation and economic growth.
Discover more about emerging drugs for chronic sinusitis with nasal polyps @ Chronic Rhinosinusitis with Nasal Polyps Drugs
Recent Developments in the Chronic Rhinosinusitis with Nasal Polyps Market
- In February 2026, GSK announced that the European Commission had authorized EXDENSUR (depemokimab) as an add-on treatment alongside intranasal corticosteroids for adults with severe CRSwNP who remain insufficiently controlled despite systemic corticosteroids and/or surgery.
- In January 2026, GSK reported that Japan’s Ministry of Health, Labour and Welfare approved EXDENSUR (depemokimab) for the treatment of CRSwNP in patients inadequately controlled with standard therapy.
- In December 2025, the US FDA approved depemokimab for severe asthma but did not approve the CRSwNP indication, without providing detailed reasons. GSK has expressed continued confidence in the therapy’s potential for CRSwNP and is maintaining discussions with the FDA.
- In October 2025, TEZSPIRE was approved in the US for the add-on maintenance treatment of adult and paediatric patients aged 12 years and older with inadequately controlled CRSwNP, making it the first and only biologic that targets thymic stromal lymphopoietin (TSLP) to be approved for CRSwNP.
- In September 2025, Upstream Bio reported positive top-line results from the Phase II VIBRANT trial evaluating verekitug for the treatment of CRSwNP. In the 24-week study, verekitug administered at 100 mg every 12 weeks met its primary endpoint, demonstrating a statistically significant and clinically meaningful placebo-adjusted reduction in endoscopic nasal polyp score (NPS) of -1.8.
What is Chronic Rhinosinusitis with Nasal Polyps?
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a long-lasting inflammatory condition of the nose and sinuses in which soft, painless, noncancerous growths, called nasal polyps, develop inside the nasal passages or sinus cavities. These polyps form when the lining of the nose becomes persistently swollen and irritated, often due to immune system dysfunction. People with CRSwNP commonly experience symptoms such as nasal blockage, reduced or lost sense of smell, facial pressure, congestion, and recurring sinus infections. Because the inflammation is ongoing and the polyps tend to recur even after treatment, CRSwNP is considered a chronic condition that often requires long-term medical management.
Chronic Rhinosinusitis with Nasal Polyps Epidemiology Segmentation
The CRSwNP epidemiology section provides insights into the historical and current CRSwNP patient pool and forecasted trends for the leading markets. The US had the highest diagnosed prevalent cases of CRSwNP in the 7MM, with around 2 million cases in 2025. The gender distribution of the disease suggests a male predominance in the US, with 55% of the diagnosed prevalent cases of CRSwNP being males.
The CRSwNP treatment market report proffers epidemiological analysis for the study period 2022-2036 in the leading markets, segmented into:
- Prevalent Cases of CRS
- Diagnosed Prevalent Cases of CRS
- Diagnosed Prevalent Cases of CRSwNP
- Gender-specific Diagnosed Prevalent Cases of CRSwNP
- Total Treated Cases of CRSwNP
Chronic Rhinosinusitis with Nasal Polyps Market Report Metrics
Details
Study Period
2022-2036
Coverage 7MM [The United States, the EU4 (Germany, France, Italy, and Spain), the United
Kingdom, and Japan].
Chronic Rhinosinusitis with Nasal Polyps Epidemiology Segmentation Prevalent Cases of CRS, Diagnosed Prevalent Cases of CRS, Diagnosed Prevalent Cases
of CRSwNP, Gender-specific Diagnosed Prevalent Cases of CRSwNP, and Total Treated
Cases of CRSwNP
Key Chronic Rhinosinusitis with Nasal Polyps Companies Upstream Bio, GlaxoSmithKline, Sanofi, Eli Lilly, AstraZeneca, Amgen, Regeneron
Pharmaceuticals, and others
Key Chronic Rhinosinusitis with Nasal Polyps Therapies Verekitug (UPB-101), Depemokimab (GSK3511294), Lunsekimig, LY3650150, NUCALA,
TEZSPIRE, DUPIXENT, and others
Scope of the
Chronic Rhinosinusitis with Nasal Polyps
Market Report
- Therapeutic Assessment: Chronic Rhinosinusitis with Nasal Polyps current marketed and emerging therapies
- Chronic Rhinosinusitis with Nasal Polyps Market Dynamics: Key Market Forecast Assumptions of Emerging Chronic Rhinosinusitis with Nasal Polyps Drugs and Market Outlook
- Competitive Intelligence Analysis: SWOT analysis and Market entry strategies
- Unmet Needs, KOL’s views, Analyst’s views, Chronic Rhinosinusitis with Nasal Polyps Market Access and Reimbursement
Download the report to understand CRSwNP market CAGR projections @ Chronic Rhinosinusitis with Nasal Polyps Market Analysis
Table of Contents
1 Chronic Rhinosinusitis with Nasal Polyps Market Key
Insights
2 Chronic Rhinosinusitis with Nasal Polyps Market Report
Introduction
3
Nasal Polyps Market Overview at a Glance
3.1. Market Share (%) Distribution of CRSwNP by Therapies in
2025
3.2. Market Share (%) Distribution of CRSwNP by Therapies in
2036
4
Epidemiology and Market Forecast Methodology
5
Executive Summary
6
Key Events
7
Disease Background and Overview
7.1.
Introduction
7.2.
Signs and Symptoms
7.3.
Etiology
7.4.
Causes
7.5.
Pathogenesis
7.6.
Diagnostic Approach
7.7.
Treatment and Management
8
Epidemiology and Patient Population
8.1.
Key Findings
8.2.
Methodology of Epidemiology
8.3.
Assumptions and Rationale: the 7MM
8.3.1.
The US
8.3.2.
EU4 and the UK
8.3.3.
Japan
8.4. Total Diagnosed Prevalent Cases of CRSwNP in the 7MM
8.5.
The United States
8.5.1.
Prevalent Cases of CRS in the US
8.5.2.
Diagnosed Prevalent Cases of CRS in the US
8.5.3. Diagnosed Prevalent Cases of CRSwNP in the US
8.5.4. Gender-specific Diagnosed Prevalent Cases of CRSwNP in
the US
8.5.5.
Total Treated Cases of CRSwNP in the US
8.6.
EU4 and the UK
8.7.
Japan
9
CRSwNP Patient Journey
10
Marketed CRSwNP Therapies
10.1.
Key Cross Competition
10.2.
NUCALA (mepolizumab): GlaxoSmithKline
10.2.1.
Product Description
10.2.2.
Regulatory Milestones
10.2.3.
Other Developmental Activities
10.2.4.
Clinical Trials Information
10.2.5.
Safety and Efficacy
10.2.6.
Analyst Views
10.3.
TEZSPIRE (tezepelumab): AstraZeneca/Amgen
10.4. DUPIXENT (dupilumab): Sanofi/Regeneron Pharmaceuticals
List to be continued in the final report
11
Emerging CRSwNP Drugs
11.1.
Key Cross Competition
11.2.
Verekitug (UPB-101): Upstream Bio
11.2.1.
Product Description
11.2.2.
Other Developmental Activities
11.2.3.
Clinical Development
11.2.4.
Clinical Trials Information
11.2.5.
Safety and Efficacy
11.2.6.
Analyst Views
11.3.
Depemokimab (GSK3511294): GlaxoSmithKline
List to be continued in the final report
12
CRSwNP: Market Analysis
12.1.
Key Findings
12.2.
Key CRSwNP Market Forecast Assumptions
12.3.
CRSwNP Market Outlook
12.4.
Attribute Analysis
12.5
Total Market Size of CRSwNP in the 7MM
12.6 Market Size of CRSwNP by Therapies in the 7MM
12.7
Market Size of CRSwNP in the US
12.7.1.
Total Market Size of CRSwNP in the US
12.7.2.
Market Size of CRSwNP by Therapies in the US
12.8
Market Size of CRSwNP in EU4 and the UK
12.9
Market Size of CRSwNP in Japan
13
KOL Views on CRSwNP
13.1.
The United States
13.2.
The EU4 and the UK
13.3.
Japan
14
CRSwNP Market SWOT Analysis
15
CRSwNP Market Unmet Needs
16
Reimbursement and Market Access
16.1
The US
16.2
In EU4 and the UK
16.3
Japan
17.
Bibliography
18
Abbreviations and Acronyms
19
CRSwNP Market Report Methodology
Related Reports
Chronic Rhinosinusitis with Nasal Polyps Clinical Trial Analysis
Chronic Rhinosinusitis with Nasal Polyps Pipeline Insight – 2026 report provides comprehensive insights about the pipeline landscape, pipeline drug profiles, including clinical and non-clinical stage products, and the key CRSwNP companies, including Keymed Biosciences Co., Ltd., GlaxoSmithKline, Genrix (Shanghai) Biopharmaceutical Co., Ltd., Guangdong Hengrui Pharmaceutical Co., Ltd, and others.
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Nasal Polyps Market Insights, Epidemiology, and Market Forecast – 2034 report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the market trends, market drivers, market barriers, and key nasal polyps companies including Sanofi, Regeneron, GSK, Optinose, AstraZeneca, Novartis, Intersect ENT Inc., Teva Pharmaceutical Industries, Merck & Co., Cipla Ltd., Dr. Reddy’s Laboratories, Genentech (Roche), Sun Pharmaceutical Industries, Lyra Therapeutics, and others.
About DelveInsight
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Contact Us
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Tengo varias preguntas sobre esto a ver si me podiais aclarar:
-¿Puedo hacer un ingreso regular de 800 euros y me cobran 0euos de comisiones y mto.?
-¿Puedo sacar el dinero cuando quiera?,¿todo ó tengo entendido que hay que mantener un mínimo de 100 euros los 30 meses?
-No necesito pero me obligan a sacar una tarjeta de débito que me cuesta 11 euros el primer año y 22 euros la renovación, también otra de credito que me cuesta 0 euros el primer año y 35 euros la renovación.
¿Hay que mantenerlas 13 meses?
¿Puedo cancelar alguna de ellas desde el principio?
¿Puedo cancelar alguna de ellas antes de la renovación?
¿Hay alguna tarjeta de credito más barata?
Aparte de la cuenta nómina he visto que también que para que te den la tv también se puede sacar una cuenta tarifa plana básica o personal, ¿sabeis algo de estas cuentas?¿que requisitos tienen?
Muchas gracias a todos por responder
Yo fui a informarme y te cuento. Únicamente admiten los ingresos regulares en el caso de que seas autónomo. Te abren una cuenta Tarifa Plana Cero que está exenta de comisiones y presenta alguna ventaja más. Sobre dejar un mínimo de saldo en la cuenta no es necesario, pero sí te obligan a mantener varias tarjetas durante los 30 meses con un coste aproximado de 100 euros anuales.
hola buenas!
me llamo javi y estoy dudando de que banco, me puede dar mas beficios, sin sorpresas por domiciliar la nomina, ya que llevo años en la caixa y no me da nada ningun beneficio. es mas me rechazan los prestamos que solicito, ni siquiera una targeta de credito, por alegan de que siempre esta a cero la cuenta, yo cuando cobro la nomina dejo el dinero para los pagos, y saco el resto, pues no me fio, de que un dia me quede sin dinero, ya que esta todo muy mal, corre riesgo mi dinero o mis ahorros en el banco?? muchas gracias y un cordial saludo.
javi
NO TE EXTRAÑE QUE NO TE DEN LOS PTMOS, PORQUE LO QUE VEN ES QUE NO TIENES CAPACIDAD DE AHORRO PORQUE SIEMPRE DEJAS LA CTA. EN MINIMOS, ASI NINGUN BANCO TE LO VA A CONCEDER. TAMBIEN ES VERDAD QUE LA CAIXA, COMO TANTAS OTRAS CAJAS, TIENE EL PUÑO CERRADO PARA LOS RIESGOS, PARA REMONTAR. NO TE PREOCUPES, QUE POR UNA NOMINA NO CREO QUE NINGUN BANCO SE COJA LAS MANOS. LOS QUE SE TIENEN QUE PREOCUPAR SON LOS QUE TIENEN DÉPÓSITOS Y FONDOS EN BANCOS DE DUDOSA ACTIVIDAD. LA GENTE SE PIENSA QUE PORQUE LES DEN UN 7% YA ES UN GRAN BANCO Y SE EQUIVOCAN. LO QUE LES PASA ES QUE EL BANCO DE ESPAÑA LES PRESTA EL DINERO MAS CARO Y POR ESO OPTAN POR CONSEGUIRLO EN EL MERCADO MONETARIO, Y SI EL BANCO DE ESPAÑA NO SE FIA DE ELLOS, VA Y SE FIA LA GENTE. QUE LOS BANCOS NOES LA ADMON PUBLICA, ABRAN OS OJOS.
Hola , cuando vallais al banco queos dejen lo que hay que pagar de irpf y de iva sobre el valor de la tele ya que en la mayoria de bancos esto no lo dicen y luego llagan las sorpresas .A mi ya me ha pasado con la promoción del portatil y nunca me hablaros de esto . Cuidado
Yo he estado calculando y la tele entre unas cosas y otras te sale sobre unos 250euros que tampoco regalan tanto .Hay oficinas en las que han dado la occión de poner un dinero a plazo fijo a 12meses de 9300euros o 6800euros a 18 meses.
No es ningún chollo. Te obligan a contratar dos tarjetas de crédito que tienes que pagar porque las tienes que mantener 13 meses por lo menos y además llevan unos costes desproporcionados si las utilizas. En total, no usando las tarjetas y anulándolas una vez cumplidos los 13 meses puedes ahorrar unos 38 euros con respecto al precio de ese televisor en una gran superficie. Y además luego vendrá que te cobran para hacienda la retención correspondiente, por lo que probablemente incluso en las mejores condiciones te cueste más que si ahorras un poco y lña compras directamente.
Creó que teneis toda la razón, que aqui no te regalan nada, ya que a mí me paso con unas sartenes que regalaban el banco bilbao, que al final entre el irpf y el descuento de Hacienda, al final me salieron caras, así es que no os tomen el pelo, que al final siempre esta la letra pequeña que es la que nos joroba, por no decir otra cosa.
Yo saque el portatil y ahora me he sacado la TV LCD 32. Estas promos no hay que declararlas. No es obligado domiciliar nomina. Si, meter en la cuenta 800€ todos los meses en un margen de 10 dias. Cero matacero, pero cero,cero, cero de gastos de mantenimiento, ni por recibos, ni por el correo a casa, ni por transfer. Las tarjets gratis el 1er año. Resto fuera. Dadas de baja Menos la de debito. Banesto no pierde nada, ganar, gana clientes que es el proposito de esta promo. Precio de portatil y tv 32 en mercao unos 900€ los 2. En banest 197€. Los hay mejores, nos ha jodio! portatiles a 1200€, TV LCD 32 a 1000€. Señores, son lentejas. Relacion calida-precio-promo es cojonud…….Un saludit a los viandantes.
hola , no se si llegara mi comentario pero os voi a esplicar. esto es el cuento de la abuela. mira yo tengo el portatil. y he cogio tab la tele, pero sabeis ke?, me ha pasado de todo. os esplico. primero me cobran 74 euros y 25 euros de unas tarjetas que yo no las he visto aparecer por mi casa , me cabreo con el banco. llamo y pido esplicaciones. me dicen que van en la promocion, nunca jamas nadie me informo de las tarjetas, no me devuelven el dinero. me cabreo y me dicen que llame aun numero de tefono para darlas de baja, se pasan los dias, intentamos darlas de baja. largas y larga, que si este numero de tefono que si el otro bla bla bla. conseguimos hablar y nos dicen que tenemos que cambiar el contrato a tarifa plana o no se ke historias, llamando al banco se pasan los dias, largas y largas. me cabreo y estoi por suspender todo, me dicen que si lo quiero cambiar y dar de baja las tarjetas que nunca he tenido. tengo que pagar comisiones cada seis meses de doce y pico euros, y que si no quiero que me cobren comisiones tengo que ir todos los meses al banco a hacerlo yo, ufffffffffff.aun hay mas. me dan de baja y me hacen la tarifa plana, se equivocan un monton de veces. me hacen pasar muchos cabreos.y al final cuando llego a casa me han cobrado 25, 50 euros. y llamo por telefono y se lo digo , me dicen claro por dar de baja la otra cuenta , la madre que los pario. ladrones. o sea os digo que la tele no sale regalada, se la cobran y muy bien cobrada , nadie da nada por nada. en cuento termine de pagar lo que debo quito todas las cuentas del banesto.espero que alguien me lea y que me conteste gracias .
Banesto ha jodido a mi marido y a un amigo tambien. Para mi, despues de Banco de Andalucía son los peores. Y quieran creerlo o no ni la television ni el portátil te lo regalan.. como no cumplas cualquiera de las reglas te sancionan con 300 y pico de euros.. porque nos hemos mudado de casa y los recibos domiciados se cortaron «temporalmente» la sancion fue de mas de 300 euros.. y el cabreo q te llevas cuando ves lo q te han descontado y luego para ir a reclamarlos.. y como te tratan !! en fin.. espero que Banesto sea lo primero en undirse en el fin del mundo!!
CHOLLO!!!!!!!!!JAJAJAJAJA…….NO ES NINGUN CHOLLO!!!!!!! te cobran 100 € de gastos de manipulacion, mas 150 € en tarjetas durante 2 años, mas 6 € mensuales de mantenimiento de cuenta durante 30 meses, total que pagas 630 Euros por un ordenador o una TV que su valor seguro que no llega a 500 €. Y encima si vas a cancelar la cuenta cuando cumples los 30 meses requeridos te hacen esperar dos horas para decirte que no tienen linea de telefono para dar de baja la cuenta, cosa que no para nunca cuando vas a contratarlo. Y del trato que dispensan….., es el mismo que si vas con un fajo de billetes de 500 € por los CO-JONES
Banesto «premia», menuda falacia…
No hay ningún banco que premie a nadie.
BANESTO NECESITA NUESTRAS NÓMINAS, Y EN CUANTO VAS UN POCO JUSTO, COMO BUENOS JUDÍOS Y ÁVAROS QUE SON, TE ACOSAN Y MACHACAN, Y TE SACAN HASTA LAS ENTRAÑAS EN COMISIONES.
DESPUÉS EL ESTADO APOYA A LOS BANCOS, CON LA EXCUSA DE QUE SI CAEN LOS BANCOS CAEMOS TODOS. LOS BANCOS NECESITAN UN BOICOT DE VEZ EN CUANDO, PARA QUE NO NOS RESTREGUEN POR LA CARA SUS BENEFICIOS.
POR CIERTO, LO QUE MÁS FASTIDIA A UN BANCO ES UNA RECLAMACIÓN EN LA OFICINA DEL CONSUMIDOR Y OTRA AL BANCO DE ESPAÑA.
ES POR DAR PISTAS…