PR Newswire
LAS VEGAS, Feb. 2, 2026
The market for TIGIT inhibitors is expected to grow significantly in the coming years. This is due to the increasing number of patients who are being diagnosed with NSCLC, RCC, colorectal cancer, lung cancer, and many more indications; the growing awareness of TIGIT inhibitors; and the increasing number of emerging drugs such as domvanalimab (Arcus Biosciences and Gilead Sciences), rilvegostomig (AstraZeneca, Compugen, and Daiichi Sankyo), Casdozokitug (CHS-388) (Coherus Biosciences), COM902 (Compugen), and others.
LAS VEGAS, Feb. 2, 2026 /PRNewswire/ — DelveInsight’s TIGIT Inhibitors Market Size, Target Population, Competitive Landscape & Market Forecast report includes a comprehensive understanding of current treatment practices, addressable patient population, which includes top indications such as Renal cell carcinoma, Non-small cell lung cancer, Colorectal cancer, Head and neck squamous cell carcinoma, Melanoma, Esophageal squamous cell carcinoma, Endometrial cancer, Hepatocellular carcinoma, and others. The selected indications are based on approved therapies and ongoing pipeline activity. The report also provides insights into the emerging TIGIT inhibitors, market share of individual therapies, and current and forecasted market size from 2020 to 2034, segmented into leading markets (the US, EU4, UK, and Japan).
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Key Takeaways from the TIGIT Inhibitors Market Report
- The total market size of TIGIT inhibitors in the leading markets is expected to surge significantly by 2034.
- In 2024, the United States holds the largest share of the TIGIT inhibitors market among the 7MM.
- The report provides the total potential number of patients in the indications, such as Renal cell carcinoma, Non-small cell lung cancer, Colorectal cancer, Head and neck squamous cell carcinoma, Melanoma, Esophageal squamous cell carcinoma, Endometrial cancer, Hepatocellular carcinoma, and others.
- In 2024, the total incident cases of NSCLC in the US were around 205K.
- Leading TIGIT inhibitors companies, such as Arcus Biosciences, AstraZeneca, Compugen, Coherus Biosciences, Daiichi Sankyo, and others, are developing novel TIGIT inhibitors that can be available in the TIGIT inhibitors market in the coming years.
- Some of the key TIGIT inhibitors in clinical trials include Domvanalimab, Rilvegostomig, Casdozokitug (CHS-388), COM902, and others.
Discover what is the current TIGIT inhibitors market size and expected growth by 2034 @ https://www.delveinsight.com/sample-request/tigit-inhibitors-market-forecast?utm_source=cision&utm_medium=pressrelease&utm_campaign=spr
Key Factors Driving the TIGIT Inhibitors Market
- Rising Cancer Burden Worldwide: The increasing incidence of cancer worldwide, particularly solid tumors like non-small cell lung cancer, melanoma, and other hard-to-treat malignancies, is a major demand driver. Conventional therapies often fail to provide long-term responses, creating unmet clinical needs that TIGIT inhibitors aim to address through immune modulation.
- Growth of Immuno-Oncology and Checkpoint Therapy Adoption: Immune checkpoint inhibitors (e.g., PD-1/PD-L1) have become the standard of care in many cancers. TIGIT inhibitors complement these therapies by targeting additional immune pathways, enhancing anti-tumor responses, especially in combination regimens. This synergy is a central rationale shaping R&D investment and clinical strategies.
- Strategic Partnerships Strengthening TIGIT Development: Partnerships like Arcus-Gilead’s domvanalimab collaboration provide manufacturing scale, regulatory expertise, and a valuable annual R&D commitment.
- Key TIGIT Inhibitors in the Clinical Trial Pipeline: Several promising candidates in the TIGIT inhibitor clinical pipeline include domvanalimab from Arcus Biosciences and Gilead Sciences, rilvegostomig developed by AstraZeneca in collaboration with Compugen and Daiichi Sankyo, Casdozokitug (CHS-388) from Coherus Biosciences, COM902 by Compugen, and others.
TIGIT Inhibitors Market Analysis
- Currently, there is no approved TIGIT inhibitor, highlighting a significant unmet need in immuno-oncology.
- Targeting TIGIT has enabled the development of novel immunotherapies with dual mechanisms of action that combine checkpoint blockade with immune activation.
- TIGIT-directed approaches allow for selective targeting of the tumor microenvironment and demonstrate synergy with PD-1/PD-L1 inhibitors.
- These therapeutic strategies enhance antitumor immunity, reduce systemic toxicity, and help overcome immune evasion driven by alternative checkpoint overexpression.
- Recent research underscores the growing potential of small-molecule TIGIT inhibitors to enhance antitumor immunity by disrupting TIGIT-ligand interactions.
- Small-molecule TIGIT inhibitors have been shown to restore CD8⁺ T-cell and NK-cell function, thereby counteracting immune evasion mechanisms.
- Compounds such as liothyronine, azelnidipine, elraglusib, hemin, and DEL-derived hits have demonstrated preclinical efficacy across multiple immune-activating pathways.
- These small-molecule agents exert antitumor effects through immune activation, macrophage-mediated phagocytosis, ferroptosis induction, and synergy with PD-1/PD-L1 blockade.
- Small-molecule TIGIT inhibitors offer advantages, including oral bioavailability, improved tumor penetration, and potential for scalable manufacturing.
- Key challenges remain for this class, including achieving optimal selectivity, half-life, resistance management, and PK/PD optimization.
- Advances in structure-activity relationship studies, computational modeling, and rational combination strategies are accelerating progress toward clinical development.
- Inconsistencies in clinical trial outcomes have led to a sharp pullback in investment across the TIGIT inhibitor landscape.
- The anticipated approvals of domvanalimab and rilvegostomig may represent inflection points that restore industry confidence and catalyze the development of next-generation TIGIT-targeted therapies.
Learn more about who are the leading companies in TIGIT inhibitors @ TIGIT Inhibitors Analysis
TIGIT Inhibitors Competitive Landscape
Some of the potential products in the TIGIT inhibitor clinical trial landscape include domvanalimab (Arcus Biosciences and Gilead Sciences), rilvegostomig (AstraZeneca, Compugen, and Daiichi Sankyo), Casdozokitug (CHS-388) (Coherus Biosciences), COM902 (Compugen), and others.
Arcus Biosciences and Gilead Sciences’ Domvanalimab is a humanized IgG1 monoclonal antibody directed against the immune checkpoint receptor TIGIT. By preventing TIGIT from binding to its ligands CD112 and CD155, it augments CD226-driven signaling in NK cells and CD8⁺ T cells, leading to enhanced anti-tumor immune activity. Domvanalimab is currently being investigated in non-small cell lung cancer and upper gastrointestinal malignancies.
AstraZeneca, Compugen, and Daiichi Sankyo’s Rilvegostomig is a bispecific antibody that simultaneously targets PD-1 and TIGIT. By concurrently blocking PD-1 interactions with PD-L1/PD-L2 and TIGIT interactions with CD112/CD155, it reinvigorates T-cell activity and boosts CD226-mediated signaling in NK cells and CD8⁺ T cells, thereby strengthening anti-tumor immune responses. Rilvegostomig is under clinical evaluation in non-small cell lung cancer, head and neck squamous cell carcinoma, biliary tract cancer, and other solid tumors.
The anticipated launch of these emerging therapies are poised to transform the TIGIT inhibitors market landscape in the coming years. As these cutting-edge therapies continue to mature and gain regulatory approval, they are expected to reshape the TIGIT inhibitors market landscape, offering new standards of care and unlocking opportunities for medical innovation and economic growth.
To know more about which TIGIT inhibitor candidates are in late-stage clinical trials, visit @ TIGIT Inhibitors Treatment
Recent Developments in the TIGIT Inhibitors Market
- In December 2025, Compugen and AstraZeneca amended their 2018 exclusive license agreement, allowing Compugen to monetize a portion of its future royalties from rilvegostomig to strengthen its balance sheet and support the advancement of its immuno-oncology pipeline.
- In October 2025, Arcus Biosciences reported the first OS results from Arm A1 of the Phase II (EDGE-Gastric) study in patients with advanced unresectable or metastatic gastric, GEJ, or esophageal adenocarcinoma. The global, multi-arm study evaluates domvanalimab plus zimberelimab in combination with chemotherapy, in partnership with Gilead Sciences, with results to be presented at ESMO 2025.
- In September 2025, Genentech presented Phase III results at the European Society for Medical Oncology Congress 2025 (ESMO 2025) for tiragolumab in combination with atezolizumab and bevacizumab as first-line treatment in patients with untreated locally advanced or metastatic Hepatocellular Carcinoma (HCC).
What are TIGIT Inhibitors?
TIGIT inhibitors are a class of cancer immunotherapy agents designed to enhance the body’s immune response against tumors by targeting TIGIT (T cell immunoreceptor with Ig and ITIM domains), an immune checkpoint receptor expressed on T cells and natural killer (NK) cells. TIGIT interacts with ligands such as CD155 (PVR) on tumor cells and antigen-presenting cells to deliver inhibitory signals that suppress immune cell activation and cytokine production, enabling tumors to evade immune surveillance. By blocking the TIGIT pathway, TIGIT inhibitors restore T-cell and NK-cell function, promote antitumor immunity, and can synergize with other immune checkpoint inhibitors, particularly PD-1/PD-L1 inhibitors. As a result, TIGIT inhibitors are being actively investigated across multiple solid tumors and hematological malignancies as a promising next-generation immuno-oncology strategy.
TIGIT Inhibitors Epidemiology Segmentation
The TIGIT inhibitors market report is a comprehensive and specialized analysis, offering in-depth epidemiological insights for the study period 2020-2034 across the leading markets. The TIGIT inhibitors target patient pool is segmented into:
- Total Cases of Selected Indications for TIGIT Inhibitors
- Total Eligible Patient Pool for TIGIT Inhibitors in Selected Indications
- Total Treated Cases in Selected Indications for TIGIT Inhibitors
TIGIT Inhibitors Report Metrics
Details
Study Period
2020-2034
TIGIT Inhibitors Report Coverage 7MM [The United States, the EU-4 (Germany, France, Italy, and Spain), the United Kingdom, and Japan]
Key Indications Covered in the Report Renal cell carcinoma, Non-small cell lung cancer, Colorectal cancer, Head and neck squamous cell
carcinoma, Melanoma, Esophageal squamous cell carcinoma, Endometrial cancer, Hepatocellular carcinoma,
and others
TIGIT Inhibitors Target Patient Pool Segmentation Total Cases of Selected Indications for TIGIT Inhibitors, Total Eligible Patient Pool for TIGIT
Inhibitors in Selected Indications, and Total Treated Cases in Selected Indications for TIGIT
Inhibitors
Key TIGIT Inhibitors Companies
Arcus Biosciences, AstraZeneca, Compugen, Coherus Biosciences, Daiichi Sankyo, and others
Key TIGIT Inhibitors
Domvanalimab, Rilvegostomig, Casdozokitug (CHS-388), COM902, and others
Scope of the
TIGIT Inhibitors
Market Report
- TIGIT Inhibitors Therapeutic Assessment: TIGIT Inhibitors’ current marketed and emerging therapies
- TIGIT Inhibitors Market Dynamics: Conjoint Analysis of Emerging TIGIT Inhibitors Drugs
- Competitive Intelligence Analysis: SWOT analysis and Market entry strategies
- Unmet Needs, KOL’s views, Analyst’s views, TIGIT Inhibitors Market Access and Reimbursement
Discover emerging bispecific and combo therapies (TIGIT + PD-1 / PD-L1) @ TIGIT Inhibitors Clinical Trials
Table of Contents
1
TIGIT Inhibitors Market Key Insights
2
TIGIT Inhibitors Market Report Introduction
3
Executive Summary
4
Key Events
5
Epidemiology and Market Forecast Methodology
6
TIGIT Inhibitors Market Overview at a Glance
6.1 Clinical Landscape (Analysis by Molecule Type, Phase, and Route of
Administration [RoA])
6.2 Market Share (%) Distribution by Class of TIGIT Inhibitors in 2028
6.3 Market Share (%) Distribution by Class of TIGIT Inhibitors in 2036
7
Background and Overview
8
Treatment Guidelines
9
Epidemiology and Patient Population
9.1
Key Findings
9.2
Assumptions and Rationale: 7MM
9.3
Epidemiology Scenario in the 7MM
9.3.1 Total Cases of Selected Indications for TIGIT Inhibitors in the 7MM
9.3.2 Total Eligible Patient Pool for TIGIT Inhibitor in Selected Indications
in the 7MM
9.3.3 Total Treated Cases in Selected Indications for TIGIT Inhibitor in the
7MM
10
Emerging TIGIT Inhibitors
10.1
Key Cross Competition
10.2
Domvanalimab: Arcus Biosciences and Gilead Sciences
11.2.1
Product Description
11.2.2
Other Development Activities
11.2.3
Clinical Development
11.2.3.1
Clinical Trial Information
11.2.4
Safety and Efficacy
11.2.5
Analyst’s Views
11.3
Rilvegostomig: AstraZeneca and Compugen
List to be continued in the report….
12
TIGIT Inhibitors Market: Seven Major Market Analysis
12.1
Key Findings
12.2
TIGIT Inhibitors Market Outlook
12.3
Conjoint Analysis
12.4
Key TIGIT Inhibitors Market Forecast Assumptions
12.5
Total TIGIT Inhibitors Market Size by Country in the 7MM
12.6
Total TIGIT Inhibitors Market Size by Indications in the 7MM
12.7
Total TIGIT Inhibitors Market Size by Therapies in the 7MM
12.8
The United States TIGIT Inhibitors Market Size
12.8.1
Total Market Size by Indications in the United States
12.8.2
Total Market Size by Therapies in the United States
12.9
EU4 and the UK TIGIT Inhibitors Market Size
12.10
Japan TIGIT Inhibitors Market Size
13
TIGIT Inhibitors Market Unmet Needs
14
TIGIT Inhibitors Market SWOT Analysis
15
KOL Views on TIGIT Inhibitors
16
TIGIT Inhibitors Market Access and Reimbursement
16.1
The United States
16.2
In EU4 and the UK
16.3
Japan
16.4 Summary and Comparison of Market Access and Pricing Policy Developments
in 2025
17
Bibliography
18
TIGIT Inhibitors Market Report Methodology
Related Reports
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About DelveInsight
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Tengo varias preguntas sobre esto a ver si me podiais aclarar:
-¿Puedo hacer un ingreso regular de 800 euros y me cobran 0euos de comisiones y mto.?
-¿Puedo sacar el dinero cuando quiera?,¿todo ó tengo entendido que hay que mantener un mínimo de 100 euros los 30 meses?
-No necesito pero me obligan a sacar una tarjeta de débito que me cuesta 11 euros el primer año y 22 euros la renovación, también otra de credito que me cuesta 0 euros el primer año y 35 euros la renovación.
¿Hay que mantenerlas 13 meses?
¿Puedo cancelar alguna de ellas desde el principio?
¿Puedo cancelar alguna de ellas antes de la renovación?
¿Hay alguna tarjeta de credito más barata?
Aparte de la cuenta nómina he visto que también que para que te den la tv también se puede sacar una cuenta tarifa plana básica o personal, ¿sabeis algo de estas cuentas?¿que requisitos tienen?
Muchas gracias a todos por responder
Yo fui a informarme y te cuento. Únicamente admiten los ingresos regulares en el caso de que seas autónomo. Te abren una cuenta Tarifa Plana Cero que está exenta de comisiones y presenta alguna ventaja más. Sobre dejar un mínimo de saldo en la cuenta no es necesario, pero sí te obligan a mantener varias tarjetas durante los 30 meses con un coste aproximado de 100 euros anuales.
hola buenas!
me llamo javi y estoy dudando de que banco, me puede dar mas beficios, sin sorpresas por domiciliar la nomina, ya que llevo años en la caixa y no me da nada ningun beneficio. es mas me rechazan los prestamos que solicito, ni siquiera una targeta de credito, por alegan de que siempre esta a cero la cuenta, yo cuando cobro la nomina dejo el dinero para los pagos, y saco el resto, pues no me fio, de que un dia me quede sin dinero, ya que esta todo muy mal, corre riesgo mi dinero o mis ahorros en el banco?? muchas gracias y un cordial saludo.
javi
NO TE EXTRAÑE QUE NO TE DEN LOS PTMOS, PORQUE LO QUE VEN ES QUE NO TIENES CAPACIDAD DE AHORRO PORQUE SIEMPRE DEJAS LA CTA. EN MINIMOS, ASI NINGUN BANCO TE LO VA A CONCEDER. TAMBIEN ES VERDAD QUE LA CAIXA, COMO TANTAS OTRAS CAJAS, TIENE EL PUÑO CERRADO PARA LOS RIESGOS, PARA REMONTAR. NO TE PREOCUPES, QUE POR UNA NOMINA NO CREO QUE NINGUN BANCO SE COJA LAS MANOS. LOS QUE SE TIENEN QUE PREOCUPAR SON LOS QUE TIENEN DÉPÓSITOS Y FONDOS EN BANCOS DE DUDOSA ACTIVIDAD. LA GENTE SE PIENSA QUE PORQUE LES DEN UN 7% YA ES UN GRAN BANCO Y SE EQUIVOCAN. LO QUE LES PASA ES QUE EL BANCO DE ESPAÑA LES PRESTA EL DINERO MAS CARO Y POR ESO OPTAN POR CONSEGUIRLO EN EL MERCADO MONETARIO, Y SI EL BANCO DE ESPAÑA NO SE FIA DE ELLOS, VA Y SE FIA LA GENTE. QUE LOS BANCOS NOES LA ADMON PUBLICA, ABRAN OS OJOS.
Hola , cuando vallais al banco queos dejen lo que hay que pagar de irpf y de iva sobre el valor de la tele ya que en la mayoria de bancos esto no lo dicen y luego llagan las sorpresas .A mi ya me ha pasado con la promoción del portatil y nunca me hablaros de esto . Cuidado
Yo he estado calculando y la tele entre unas cosas y otras te sale sobre unos 250euros que tampoco regalan tanto .Hay oficinas en las que han dado la occión de poner un dinero a plazo fijo a 12meses de 9300euros o 6800euros a 18 meses.
No es ningún chollo. Te obligan a contratar dos tarjetas de crédito que tienes que pagar porque las tienes que mantener 13 meses por lo menos y además llevan unos costes desproporcionados si las utilizas. En total, no usando las tarjetas y anulándolas una vez cumplidos los 13 meses puedes ahorrar unos 38 euros con respecto al precio de ese televisor en una gran superficie. Y además luego vendrá que te cobran para hacienda la retención correspondiente, por lo que probablemente incluso en las mejores condiciones te cueste más que si ahorras un poco y lña compras directamente.
Creó que teneis toda la razón, que aqui no te regalan nada, ya que a mí me paso con unas sartenes que regalaban el banco bilbao, que al final entre el irpf y el descuento de Hacienda, al final me salieron caras, así es que no os tomen el pelo, que al final siempre esta la letra pequeña que es la que nos joroba, por no decir otra cosa.
Yo saque el portatil y ahora me he sacado la TV LCD 32. Estas promos no hay que declararlas. No es obligado domiciliar nomina. Si, meter en la cuenta 800€ todos los meses en un margen de 10 dias. Cero matacero, pero cero,cero, cero de gastos de mantenimiento, ni por recibos, ni por el correo a casa, ni por transfer. Las tarjets gratis el 1er año. Resto fuera. Dadas de baja Menos la de debito. Banesto no pierde nada, ganar, gana clientes que es el proposito de esta promo. Precio de portatil y tv 32 en mercao unos 900€ los 2. En banest 197€. Los hay mejores, nos ha jodio! portatiles a 1200€, TV LCD 32 a 1000€. Señores, son lentejas. Relacion calida-precio-promo es cojonud…….Un saludit a los viandantes.
hola , no se si llegara mi comentario pero os voi a esplicar. esto es el cuento de la abuela. mira yo tengo el portatil. y he cogio tab la tele, pero sabeis ke?, me ha pasado de todo. os esplico. primero me cobran 74 euros y 25 euros de unas tarjetas que yo no las he visto aparecer por mi casa , me cabreo con el banco. llamo y pido esplicaciones. me dicen que van en la promocion, nunca jamas nadie me informo de las tarjetas, no me devuelven el dinero. me cabreo y me dicen que llame aun numero de tefono para darlas de baja, se pasan los dias, intentamos darlas de baja. largas y larga, que si este numero de tefono que si el otro bla bla bla. conseguimos hablar y nos dicen que tenemos que cambiar el contrato a tarifa plana o no se ke historias, llamando al banco se pasan los dias, largas y largas. me cabreo y estoi por suspender todo, me dicen que si lo quiero cambiar y dar de baja las tarjetas que nunca he tenido. tengo que pagar comisiones cada seis meses de doce y pico euros, y que si no quiero que me cobren comisiones tengo que ir todos los meses al banco a hacerlo yo, ufffffffffff.aun hay mas. me dan de baja y me hacen la tarifa plana, se equivocan un monton de veces. me hacen pasar muchos cabreos.y al final cuando llego a casa me han cobrado 25, 50 euros. y llamo por telefono y se lo digo , me dicen claro por dar de baja la otra cuenta , la madre que los pario. ladrones. o sea os digo que la tele no sale regalada, se la cobran y muy bien cobrada , nadie da nada por nada. en cuento termine de pagar lo que debo quito todas las cuentas del banesto.espero que alguien me lea y que me conteste gracias .
Banesto ha jodido a mi marido y a un amigo tambien. Para mi, despues de Banco de Andalucía son los peores. Y quieran creerlo o no ni la television ni el portátil te lo regalan.. como no cumplas cualquiera de las reglas te sancionan con 300 y pico de euros.. porque nos hemos mudado de casa y los recibos domiciados se cortaron «temporalmente» la sancion fue de mas de 300 euros.. y el cabreo q te llevas cuando ves lo q te han descontado y luego para ir a reclamarlos.. y como te tratan !! en fin.. espero que Banesto sea lo primero en undirse en el fin del mundo!!
CHOLLO!!!!!!!!!JAJAJAJAJA…….NO ES NINGUN CHOLLO!!!!!!! te cobran 100 € de gastos de manipulacion, mas 150 € en tarjetas durante 2 años, mas 6 € mensuales de mantenimiento de cuenta durante 30 meses, total que pagas 630 Euros por un ordenador o una TV que su valor seguro que no llega a 500 €. Y encima si vas a cancelar la cuenta cuando cumples los 30 meses requeridos te hacen esperar dos horas para decirte que no tienen linea de telefono para dar de baja la cuenta, cosa que no para nunca cuando vas a contratarlo. Y del trato que dispensan….., es el mismo que si vas con un fajo de billetes de 500 € por los CO-JONES
Banesto «premia», menuda falacia…
No hay ningún banco que premie a nadie.
BANESTO NECESITA NUESTRAS NÓMINAS, Y EN CUANTO VAS UN POCO JUSTO, COMO BUENOS JUDÍOS Y ÁVAROS QUE SON, TE ACOSAN Y MACHACAN, Y TE SACAN HASTA LAS ENTRAÑAS EN COMISIONES.
DESPUÉS EL ESTADO APOYA A LOS BANCOS, CON LA EXCUSA DE QUE SI CAEN LOS BANCOS CAEMOS TODOS. LOS BANCOS NECESITAN UN BOICOT DE VEZ EN CUANDO, PARA QUE NO NOS RESTREGUEN POR LA CARA SUS BENEFICIOS.
POR CIERTO, LO QUE MÁS FASTIDIA A UN BANCO ES UNA RECLAMACIÓN EN LA OFICINA DEL CONSUMIDOR Y OTRA AL BANCO DE ESPAÑA.
ES POR DAR PISTAS…